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- Title
Fetuin-A is not associated with mortality in chronic kidney disease.
- Authors
Ix, J. H.; Shlipak, M. G.; Sarnak, M. J.; Beck, G. J.; Greene, T.; Wang, X.; Kusek, J. W.; Collins, A. J.; Levey, A. S.; Menon, V.
- Abstract
Fetuin-A is a serum protein that inhibits vascular calcification such that lower levels are associated with a higher prevalence of vascular calcification and mortality risk among end-stage renal disease populations. We analyzed data of 822 persons in the Modification of Diet in Renal Disease study, a randomized, controlled trial of persons with predominantly non-diabetic stage 3–4 chronic kidney disease (CKD). Serum fetuin-A levels were measured in baseline serum. Survival status and cause of death were determined by the National Death Index. Cox proportional hazard models evaluated the association of fetuin-A levels with all-cause and cardiovascular mortality. Glomerular filtration ranged from 13 to 55 ml per min per 1.73 m2. During a median follow-up of 9.5 years, 25% of persons died from any cause and 12% died from a cardiovascular cause. Compared to the lowest tertile, no association was found between the highest fetuin-A tertile and all-cause or cardiovascular mortality. Similarly, no association was found between fetuin-A as a continuous variable and all-cause or cardiovascular mortality. Our study shows that serum fetuin-A levels are not related to all-cause or cardiovascular mortality among persons with predominantly non-diabetic stage 3 or 4 CKD.Kidney International (2007) 72, 1394–1399; doi:10.1038/sj.ki.5002549; published online 19 September 2007
- Subjects
KIDNEY diseases; CHRONIC kidney failure; CHRONIC diseases; DIET in disease; LABORATORY rats
- Publication
Kidney International, 2007, Vol 72, Issue 11, p1394
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/sj.ki.5002549