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- Title
FDG-PET in cervical cancer: staging, re-staging and follow-up.
- Authors
Bjurberg, Maria; Kjellén, Elisabeth; Ohlsson, Tomas; Ridderheim, Mona; Brun, Eva; Kjellén, Elisabeth
- Abstract
<bold>Background: </bold>Correctly visualising the extent of the disease in cervical cancer is difficult with today's conventional imaging modalities. This paper presents the interim analysis of an on-going prospective study to evaluate the potential role of FDG-PET with software fusion with CT images in 3 different clinical settings of cervical cancer. <bold>Methods: </bold>In Group 1, 10 patients with early stage cervical cancer underwent FDG-PET 6 months after surgery. Group 2 consisted of 17 patients with locally advanced cervical cancer who underwent FDG-PET as part of the staging procedure. In Group 3, 12 patients with verified relapse and 3 patients with a strong suspicion thereof underwent FDG-PET before starting any therapy. The FDG-PET results were compared with the results of the standard conventional work-up. All patients had a follow-up time of at least 6 months. <bold>Results: </bold>All FDG-PET scans in Group 1 were true negative. In Group 2, FDG-PET detected previously unknown locations of metastases in 4 patients, and a synchronous pulmonary carcinoma in 1 patient, resulting in a change in treatment plan for 4 patients. One false negative FDG-PET result was recorded. In Group 3, FDG-PET results led to a change in treatment plan for 3 patients. <bold>Conclusions: </bold>We conclude that FDG-PET provides crucial information in the pre-treatment staging procedure in patients with locally advanced or relapsed cervical cancer. However, in the follow-up of early cervix cancer, FDG-PET 6 months post-operatively offered no clinical benefit in this small group of patients.
- Subjects
CERVICAL cancer diagnosis; MEDICAL imaging systems; POSITRON emission tomography; CANCER invasiveness; PREVENTIVE medicine; CANCER treatment; CANCER relapse; CANCER; DEOXY sugars; LONGITUDINAL method; HEALTH outcome assessment; RADIOPHARMACEUTICALS; TUMOR classification; CERVIX uteri tumors; PREDICTIVE tests; DIAGNOSIS; TUMOR treatment
- Publication
Acta Obstetricia et Gynecologica Scandinavica, 2007, Vol 86, Issue 11, p1385
- ISSN
0001-6349
- Publication type
journal article
- DOI
10.1080/00016340701625388