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- Title
Steroids in aminoglycoside-containing ear drops: Do they reduce cochlear toxicity?
- Authors
Blakley, Brian W.; Alsaleh, Saad; Dewji, Zameel; Qureshy, Kaiser; Berard, Sylvie; Xie, Ling
- Abstract
Objectives/Hypothesis To determine whether betamethasone (BM) reduces the cochlear toxicity of otic gentamicin (GM) if given together. Study Design Controlled animal study. Methods Thirty-four mice were assigned at random to receive intratympanic injections of either 0.1 % BM (11 mice), 0.3% GM (13 mice), or a combination of both (GM/BM) with benzalkonium chloride (10 mice) in the left ear (treated) and saline on the right (untreated). Six injections were given on alternate days. Auditory brainstem response thresholds were assessed at 1 month, 2 months, and >2 months. Results There was a significantly greater degree of hearing loss in the BM-treated ears compared to the untreated ears (6.48 dB hearing loss, P = .007) and in the GM-treated ears compared to untreated ears (6.59 dB hearing loss, P = .010,). However, otic GM/BM and benzalkonium chloride did not cause significant additional hearing loss compared with the untreated ears (3.56 dB hearing loss, P = .242). Conclusions Our data suggest that hearing loss caused by GM otic drops may be reduced by the inclusion of BM and benzalkonium chloride. Our finding that BM alone was associated with hearing loss suggests that the benzalkonium chloride may be the protective agent in combination otic drops. Level of Evidence NA Laryngoscope, 124:1209-1213, 2014
- Subjects
COCHLEA; TREATMENT of hearing disorders; AMINOGLYCOSIDES; TREATMENT of deafness; GENTAMICIN; BENZALKONIUM chloride; THERAPEUTICS
- Publication
Laryngoscope, 2014, Vol 124, Issue 5, p1209
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1002/lary.24475