We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Allergen immunotherapy with the hypoallergenic B‐cell epitope‐based vaccine BM32 modifies IL‐10‐ and IL‐5‐secreting T cells.
- Authors
Rauber, Michèle Myriam; Möbs, Christian; Campana, Raffaela; Henning, Rainer; Schulze‐Dasbeck, Manuel; Greene, Brandon; Focke‐Tejkl, Margarete; Weber, Milena; Valenta, Rudolf; Pfützner, Wolfgang
- Abstract
Allergen immunotherapy with the hypoallergenic B-cell epitope-based vaccine BM32 modifies IL-10- and IL-5-secreting T cells Interestingly, although the BM32 vaccine does not contain T-cell epitopes specific for GP allergens, not only peptide-specific but also allergen-specific T cellular changes were detectable in BM32-treated patients. Remarkably, in addition to these immune alterations also caused by mere T-cell epitope-based peptide therapies,[9] this new approach utilizing allergen-derived B-cell epitopes also results in a lasting allergen-specific IgG antibody response.
- Subjects
T cells; ALLERGENS; ALLERGIC conjunctivitis; VACCINES; IMMUNOGLOBULIN E; IMMUNOTHERAPY; SUPPRESSOR cells; HEPATITIS B vaccines
- Publication
Allergy, 2020, Vol 75, Issue 2, p450
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.13996