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- Title
Stage-Specific Alteration and Prognostic Relationship of Serum Fumarate Hydratase Autoantibodies in Gastric Cancer.
- Authors
Sasajima, Natsuko; Sumazaki, Makoto; Oshima, Yoko; Ito, Masaaki; Yajima, Satoshi; Takizawa, Hirotaka; Wang, Hao; Li, Shu-Yang; Zhang, Bo-Shi; Yoshida, Yoichi; Hiwasa, Takaki; Shimada, Hideaki
- Abstract
The relationship between energy production and cancer is attracting attention. This study aimed to investigate the clinicopathological significance of fumarate hydratase (FH), a tricarboxylic acid cycle enzyme, in gastric cancer using autoantibodies as biomarkers. The study analyzed 116 patients who underwent gastric cancer surgery and 96 healthy controls. Preoperative serum FH autoantibody (s-FH-Ab) titers were analyzed using an immunosorbent assay with an amplified luminescent proximity homogeneous assay. Receiver operating characteristic analysis was used to determine the cutoff s-FH-Ab titer. Clinicopathological factors and prognosis were compared between the high and low s-FH-Ab groups. The s-FH-Ab levels were significantly higher in the gastric cancer group than in the control group (p = 0.01). Levels were elevated even in patients with stage I gastric cancer compared with healthy controls (p = 0.02). A low s-FH-Ab level was significantly associated with distant metastasis (p = 0.01), peritoneal dissemination (p < 0.05), and poor overall survival (p < 0.01). Multivariate analysis revealed that low s-FH-Ab levels were an independent risk factor for poor prognosis (p < 0.01). Therefore, s-FH-Ab levels may be a useful biomarker for early diagnosis and the prediction of prognosis in patients with gastric cancer.
- Subjects
STOMACH cancer; KREBS cycle; AUTOANTIBODIES; RECEIVER operating characteristic curves; CANCER prognosis; OVERALL survival
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 10, p5470
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25105470