We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Lipoxygenases at the Intersection of Infection and Carcinogenesis.
- Authors
Amoah, Abdul-Saleem; Pestov, Nikolay B.; Korneenko, Tatyana V.; Prokhorenko, Igor A.; Kurakin, Georgy F.; Barlev, Nickolai A.
- Abstract
The persisting presence of opportunistic pathogens like Pseudomonas aeruginosa poses a significant threat to many immunocompromised cancer patients with pulmonary infections. This review highlights the complexity of interactions in the host's defensive eicosanoid signaling network and its hijacking by pathogenic bacteria to their own advantage. Human lipoxygenases (ALOXs) and their mouse counterparts are integral elements of the innate immune system, mostly operating in the pro-inflammatory mode. Taking into account the indispensable role of inflammation in carcinogenesis, lipoxygenases have counteracting roles in this process. In addition to describing the structure-function of lipoxygenases in this review, we discuss their roles in such critical processes as cancer cell signaling, metastases, death of cancer and immune cells through ferroptosis, as well as the roles of ALOXs in carcinogenesis promoted by pathogenic infections. Finally, we discuss perspectives of novel oncotherapeutic approaches to harness lipoxygenase signaling in tumors.
- Subjects
LIPOXYGENASES; CARCINOGENESIS; LUNG infections; CELL communication; QUORUM sensing; IMMUNOCOMPROMISED patients; PATHOGENIC bacteria
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 7, p3961
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25073961