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- Title
Nanoparticle-Mediated Hyperthermia and Cytotoxicity Mechanisms in Cancer.
- Authors
Bala, Vanessa-Meletia; Lampropoulou, Dimitra Ioanna; Grammatikaki, Stamatiki; Kouloulias, Vassilios; Lagopati, Nefeli; Aravantinos, Gerasimos; Gazouli, Maria
- Abstract
Hyperthermia has the potential to damage cancerous tissue by increasing the body temperature. However, targeting cancer cells whilst protecting the surrounding tissues is often challenging, especially when implemented in clinical practice. In this direction, there are data showing that the combination of nanotechnology and hyperthermia offers more successful penetration of nanoparticles in the tumor environment, thus allowing targeted hyperthermia in the region of interest. At the same time, unlike radiotherapy, the use of non-ionizing radiation makes hyperthermia an attractive therapeutic option. This review summarizes the existing literature regarding the use of hyperthermia and nanoparticles in cancer, with a focus on nanoparticle-induced cytotoxicity mechanisms.
- Subjects
CYTOTOXINS; NONIONIZING radiation; BODY temperature; TUMOR microenvironment; FEVER; CANCER cells; NANOMEDICINE; HEAT stroke
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 1, p296
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25010296