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- Title
Antibacterial Effects of X-ray and MRI Contrast Media: An In Vitro Pilot Study.
- Authors
Brönnimann, Michael P.; Hirzberger, Lea; Keller, Peter M.; Gsell-Albert, Monika
- Abstract
Some radiological contrast agents have been shown to have effects on bacterial growth. In this study, the antibacterial effect and mechanism of action of iodinated X-ray contrast agents (Ultravist 370, Iopamiro 300, Telebrix Gastro 300 and Visipaque) and complexed lanthanide MRI contrast solutions (MultiHance and Dotarem) were tested against six different microorganisms. Bacteria with high and low concentrations were exposed to media containing different contrast media for various lengths of time and at pH 7.0 and 5.5. The antibacterial effect of the media was examined in further tests using agar disk diffusion analysis and the microdilution inhibition method. Bactericidal effects were found for microorganisms at low concentrations and low pH. Reductions were confirmed for Staphylococcus aureus and Escherichia coli.
- Subjects
RADIOGRAPHIC contrast media; CONTRAST media; MICROBIAL sensitivity tests; MINIMALLY invasive procedures; PILOT projects; NEUROCYSTICERCOSIS
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 4, p3470
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24043470