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Translation of Monoclonal Antibodies Pharmacokinetics from Animal to Human Using Physiologically Based Modeling in Open Systems Pharmacology (OSP) Suite: A Retrospective Analysis of Bevacizumab.
Published in:
Pharmaceutics, 2023, v. 15, n. 8, p. 2129, doi. 10.3390/pharmaceutics15082129
By:
- Pasquiers, Blaise;
- Benamara, Salih;
- Felices, Mathieu;
- Ternant, David;
- Declèves, Xavier;
- Puszkiel, Alicja
Publication type:
Article
Exposure–Response Analysis of Osimertinib in Patients with Advanced Non-Small-Cell Lung Cancer.
Published in:
Pharmaceutics, 2022, v. 14, n. 9, p. N.PAG, doi. 10.3390/pharmaceutics14091844
By:
- Rodier, Thomas;
- Puszkiel, Alicja;
- Cardoso, Evelina;
- Balakirouchenane, David;
- Narjoz, Céline;
- Arrondeau, Jennifer;
- Fallet, Vincent;
- Khoudour, Nihel;
- Guidi, Monia;
- Vidal, Michel;
- Declèves, Xavier;
- Csajka, Chantal;
- Alexandre, Jérôme;
- Cadranel, Jacques;
- Fabre, Elizabeth;
- Wislez, Marie;
- Goldwasser, François;
- Blanchet, Benoit
Publication type:
Article
Association between Olaparib Exposure and Early Toxicity in BRCA-Mutated Ovarian Cancer Patients: Results from a Retrospective Multicenter Study.
Published in:
Pharmaceuticals (14248247), 2021, v. 14, n. 8, p. 804, doi. 10.3390/ph14080804
By:
- Velev, Maud;
- Puszkiel, Alicja;
- Blanchet, Benoit;
- de Percin, Sixtine;
- Delanoy, Nicolas;
- Medioni, Jacques;
- Gervais, Claire;
- Balakirouchenane, David;
- Khoudour, Nihel;
- Pautier, Patricia;
- Leary, Alexandra;
- Ajgal, Zahra;
- Hirsch, Laure;
- Goldwasser, François;
- Alexandre, Jerome;
- Beinse, Guillaume
Publication type:
Article
Improving olaparib exposure to optimize adverse effects management.
Published in:
Therapeutic Advances in Medical Oncology, 2024, v. 16, p. 1, doi. 10.1177/17588359241248328
By:
- Sterlé, Marylise;
- Puszkiel, Alicja;
- Burlot, Chloé;
- Pereira, Eva;
- Bellesoeur, Audrey;
- De Percin, Sixtine;
- Beinse, Guillaume;
- Fumet, Jean-David;
- Favier, Laure;
- Niogret, Julie;
- Blanchet, Benoit;
- Royer, Bernard;
- Bengrine-Lefevre, Leïla;
- Schmitt, Antonin
Publication type:
Article
A Minimal PBPK Model for Plasma and Cerebrospinal Fluid Pharmacokinetics of Trastuzumab after Intracerebroventricular Administration in Patients with HER2-Positive Brain Metastatic Localizations.
Published in:
Pharmaceutical Research, 2023, v. 40, n. 11, p. 2687, doi. 10.1007/s11095-023-03614-w
By:
- Puszkiel, Alicja;
- Bousquet, Guilhem;
- Stanke-Labesque, Françoise;
- Stocco, Jeanick;
- Decq, Philippe;
- Chevillard, Lucie;
- Goutagny, Stéphane;
- Declèves, Xavier
Publication type:
Article
Pharmacokinetics/Pharmacodynamics of Dabrafenib and Trametinib for Redifferentiation and Treatment of Radioactive Iodine-Resistant Mutated Advanced Differentiated Thyroid Cancer.
Published in:
Thyroid, 2023, v. 33, n. 11, p. 1327, doi. 10.1089/thy.2023.0228
By:
- Balakirouchenane, David;
- Seban, Romain;
- Groussin, Lionel;
- Puszkiel, Alicja;
- Cottereau, Anne Ségolène;
- Clerc, Jerome;
- Vidal, Michel;
- Goldwasser, Francois;
- Arrondeau, Jennifer;
- Blanchet, Benoît;
- Huillard, Olivier
Publication type:
Article
Monitoring of Dabrafenib and Trametinib in Serum and Self-Sampled Capillary Blood in Patients with BRAFV600-Mutant Melanoma.
Published in:
Cancers, 2022, v. 14, n. 19, p. 4566, doi. 10.3390/cancers14194566
By:
- Isberner, Nora;
- Gesierich, Anja;
- Balakirouchenane, David;
- Schilling, Bastian;
- Aghai-Trommeschlaeger, Fatemeh;
- Zimmermann, Sebastian;
- Kurlbaum, Max;
- Puszkiel, Alicja;
- Blanchet, Benoit;
- Klinker, Hartwig;
- Scherf-Clavel, Oliver
Publication type:
Article
Population Pharmacokinetics/Pharmacodynamics of Dabrafenib Plus Trametinib in Patients with BRAF-Mutated Metastatic Melanoma.
Published in:
Cancers, 2020, v. 12, n. 4, p. 931, doi. 10.3390/cancers12040931
By:
- Balakirouchenane, David;
- Guégan, Sarah;
- Csajka, Chantal;
- Jouinot, Anne;
- Heidelberger, Valentine;
- Puszkiel, Alicja;
- Zehou, Ouidad;
- Khoudour, Nihel;
- Courlet, Perrine;
- Kramkimel, Nora;
- Lheure, Coralie;
- Franck, Nathalie;
- Huillard, Olivier;
- Arrondeau, Jennifer;
- Vidal, Michel;
- Goldwasser, Francois;
- Maubec, Eve;
- Dupin, Nicolas;
- Aractingi, Selim;
- Guidi, Monia
Publication type:
Article
Differential Kinase Activation in Peripheral Blood Mononuclear Cells from Non-Small-Cell Lung Cancer Patients Treated with Nivolumab.
Published in:
Cancers, 2019, v. 11, n. 6, p. 762, doi. 10.3390/cancers11060762
By:
- Noé, Gaëlle;
- Bellesoeur, Audrey;
- Golmard, Lisa;
- Thomas-Schoemann, Audrey;
- Boudou-Rouquette, Pascaline;
- Tiako Meyo, Manuela;
- Puszkiel, Alicja;
- Arrondeau, Jennifer;
- Alexandre, Jérome;
- Goldwasser, François;
- Blanchet, Benoit;
- Vidal, Michel
Publication type:
Article
Model‐Based Quantification of Impact of Genetic Polymorphisms and Co‐Medications on Pharmacokinetics of Tamoxifen and Six Metabolites in Breast Cancer.
Published in:
Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 5, p. 1244, doi. 10.1002/cpt.2077
By:
- Puszkiel, Alicja;
- Arellano, Cécile;
- Vachoux, Christelle;
- Evrard, Alexandre;
- Le Morvan, Valérie;
- Boyer, Jean‐Christophe;
- Robert, Jacques;
- Delmas, Caroline;
- Dalenc, Florence;
- Debled, Marc;
- Venat‐Bouvet, Laurence;
- Jacot, William;
- Dohollou, Nadine;
- Bernard‐Marty, Chantal;
- Laharie‐Mineur, Hortense;
- Filleron, Thomas;
- Roché, Henri;
- Chatelut, Etienne;
- Thomas, Fabienne;
- White‐Koning, Melanie
Publication type:
Article
Factors Affecting Tamoxifen Metabolism in Patients With Breast Cancer: Preliminary Results of the French PHACS Study.
Published in:
Clinical Pharmacology & Therapeutics, 2019, v. 106, n. 3, p. 585, doi. 10.1002/cpt.1404
By:
- Puszkiel, Alicja;
- Arellano, Cécile;
- Vachoux, Christelle;
- Evrard, Alexandre;
- Le Morvan, Valérie;
- Boyer, Jean‐Christophe;
- Robert, Jacques;
- Delmas, Caroline;
- Dalenc, Florence;
- Debled, Marc;
- Venat‐Bouvet, Laurence;
- Jacot, William;
- Suc, Etienne;
- Sillet‐Bach, Isabelle;
- Filleron, Thomas;
- Roché, Henri;
- Chatelut, Etienne;
- White‐Koning, Melanie;
- Thomas, Fabienne
Publication type:
Article
Pazopanib pharmacokinetically guided dose optimization in three cancer patients with gastrointestinal resection.
Published in:
2024
By:
- Tardy, Cléa;
- Puszkiel, Alicja;
- Boudou-Rouquette, Pascaline;
- De Percin, Sixtine;
- Alexandre, Jérôme;
- Berge, Marion;
- Ulmann, Guillaume;
- Blanchet, Benoit;
- Batista, Rui;
- Goldwasser, Francois;
- Thomas Schoemann, Audrey
Publication type:
Case Study
A PK-PD model linking biomarker dynamics to progression-free survival in patients treated with everolimus and sorafenib combination therapy, EVESOR phase I trial.
Published in:
Cancer Chemotherapy & Pharmacology, 2023, v. 91, n. 5, p. 413, doi. 10.1007/s00280-023-04520-z
By:
- Puszkiel, Alicja;
- You, Benoit;
- Payen, Léa;
- Lopez, Jonathan;
- Guitton, Jérôme;
- Rousset, Pascal;
- Fontaine, Juliette;
- Péron, Julien;
- Maillet, Denis;
- Tartas, Sophie;
- Bonnin, Nathalie;
- Trillet-Lenoir, Veronique;
- Colomban, Olivier;
- Augu-Denechere, Diane;
- Freyer, Gilles;
- Tod, Michel
Publication type:
Article
Clinical results of the EVESOR trial, a multiparameter phase I trial of everolimus and sorafenib combination in solid tumors.
Published in:
Cancer Chemotherapy & Pharmacology, 2023, v. 91, n. 5, p. 361, doi. 10.1007/s00280-023-04508-9
By:
- Varnier, Romain;
- Puszkiel, Alicja;
- Tod, Michel;
- Calattini, Sara;
- Payen, Lea;
- Lopez, Jonathan;
- Guitton, Jérome;
- Schwiertz, Vérane;
- Fontaine, Juliette;
- Peron, Julien;
- Maillet, Denis;
- Tartas, Sophie;
- Bonnin, Nathalie;
- Colomban, Olivier;
- Augu-Denechere, Diane;
- Freyer, Gilles;
- You, Benoit
Publication type:
Article
Extending the dosing intervals of nivolumab: model-based simulations in unselected cancer patients.
Published in:
British Journal of Cancer, 2024, v. 130, n. 11, p. 1866, doi. 10.1038/s41416-024-02659-x
By:
- Puszkiel, Alicja;
- Bianconi, Guillaume;
- Pasquiers, Blaise;
- Balakirouchenane, David;
- Arrondeau, Jennifer;
- Boudou-Rouquette, Pascaline;
- Bretagne, Marie-Claire;
- Salem, Joe-Elie;
- Declèves, Xavier;
- Vidal, Michel;
- Kramkimel, Nora;
- Guegan, Sarah;
- Aractingi, Selim;
- Huillard, Olivier;
- Alexandre, Jérôme;
- Wislez, Marie;
- Goldwasser, François;
- Blanchet, Benoit
Publication type:
Article
Exposure-response relationship of cabozantinib in patients with metastatic renal cell carcinoma treated in routine care.
Published in:
British Journal of Cancer, 2024, v. 130, n. 6, p. 961, doi. 10.1038/s41416-024-02585-y
By:
- Blanchet, Benoit;
- Xu-Vuilard, Alexandre;
- Jouinot, Anne;
- Puisset, Florent;
- Combarel, David;
- Huillard, Olivier;
- Le Louedec, Félicien;
- Thomas, Fabienne;
- Teixeira, Marcus;
- Flippot, Ronan;
- Mourey, Loic;
- Albiges, Laurence;
- Pudlarz, Thomas;
- Joly, Charlotte;
- Tournigand, Christophe;
- Chauvin, Jonathan;
- Puszkiel, Alicja;
- Chatelut, Etienne;
- Decleves, Xavier;
- Vidal, Michel
Publication type:
Article
Intra-individual Dose Escalation of Abiraterone According to Its Plasma Exposure in Patients with Progressive Metastatic Castration-Resistant Prostate Cancer: Results of the OPTIMABI Trial.
Published in:
Clinical Pharmacokinetics, 2024, v. 63, n. 7, p. 1025, doi. 10.1007/s40262-024-01396-x
By:
- Alexandre, Jérôme;
- Oudard, Stephane;
- Golmard, Lisa;
- Campedel, Luca;
- Mseddi, Mourad;
- Ladoire, Sylvain;
- Khalil, Ahmed;
- Maillet, Denis;
- Tournigand, Christophe;
- Pasquiers, Blaise;
- Goirand, Françoise;
- Berthier, Joseph;
- Guitton, Jérôme;
- Dariane, Charles;
- Joly, Florence;
- Xylinas, Evanguelos;
- Golmard, Jean Louis;
- Abdoul, Hendy;
- Puszkiel, Alicja;
- Decleves, Xavier
Publication type:
Article
Clinical Pharmacokinetics and Pharmacodynamics of Dabrafenib.
Published in:
2019
By:
- Puszkiel, Alicja;
- Noé, Gaëlle;
- Bellesoeur, Audrey;
- Kramkimel, Nora;
- Paludetto, Marie-Noëlle;
- Thomas-Schoemann, Audrey;
- Vidal, Michel;
- Goldwasser, François;
- Chatelut, Etienne;
- Blanchet, Benoit
Publication type:
journal article
Evaluation of the Interaction of Amino Acid Infusion on <sup>177</sup>Lu-Dotatate Pharmacokinetics in Patients with Gastroenteropancreatic Neuroendocrine Tumors.
Published in:
2019
By:
- Puszkiel, Alicja;
- Bauriaud-Mallet, Mathilde;
- Bourgeois, Roxane;
- Dierickx, Lawrence;
- Courbon, Frédéric;
- Chatelut, Etienne
Publication type:
journal article
Circulating Tumor DNA Measurement by Picoliter Droplet-Based Digital PCR and Vemurafenib Plasma Concentrations in Patients with Advanced BRAF-Mutated Melanoma.
Published in:
2017
By:
- Garlan, Fanny;
- Blanchet, Benoit;
- Kramkimel, Nora;
- Puszkiel, Alicja;
- Golmard, Jean-Louis;
- Noe, Gaelle;
- Dupin, Nicolas;
- Laurent-Puig, Pierre;
- Vidal, Michel;
- Taly, Valerie;
- Thomas-Schoemann, Audrey
Publication type:
journal article

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