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- Title
Impaired glucose tolerance and insulin resistance are associated with hemostatic imbalance.
- Authors
Lockard, Michael M.; Brandauer, Josef; Weiss, Edward P.; Gopinathannair, Rakesh; Kulaputana, Onanong; Hagberg, James M.
- Abstract
Impaired glucose tolerance (IGT) and insulin resistance (IR) are associated with elevated thrombosis risk, possibly via a disruption in hemostatic balance. PURPOSE: To investigate the association of IGT and IR with markers of blood coagulation and fibrinolysis. METHODS: Subjects were healthy nonsmoking sedentary men and post-menopausal women aged 50-75 years. An oral glucose tolerance test was used to assess fasting glucose and insulin concentrations, glucose and insulin areas under the curve (GAUC, IAUC), and IR by homeostatic model assessment (HOMA-IR). Hemostatic markers included plasma levels of prothrombin fragment, factor VIII antigen, factor VII antigen, tissue plasminogen activator (tPA) antigen, tPA activity, and plasminogen activator inhibitor-1 (PAI-1) activity. RESULTS: Fasting glucose correlated with tPA antigen and PAI-1 activity while fasting insulin correlated only with tPA activity. GAUC and IAUC were both correlated with PAI-1 activity, tPA activity, and tPA antigen. HOMA-IR correlated only with tPA antigen. No correlation was found with markers of blood coagulation. CONCLUSIONS: IGT and IR were associated with elevated anti-fibrinolytic activity (PAI-1 activity) and impaired fibrinolytic activity (tPA activity), but not with markers of coagulation. This implies that elevated risk of thrombosis with IGT and IR is due to impaired fibrinolysis.
- Subjects
BLOOD sugar; INSULIN resistance; THROMBOSIS risk factors; BLOOD coagulation; FIBRINOLYSIS; PROTHROMBIN; GLUCOSE; INSULIN
- Publication
FASEB Journal, 2007, Vol 21, Issue 6, pA831
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fasebj.21.6.a831-c