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- Title
Effects of zinc deficiency on the number of white blood cells in rats.
- Authors
Yui Someya; Ichinose, Takashi; Nomura, Sachiko; Kawashima, Yu; Sugiyama, Mariko; Tachiyashiki, Kaoru; Imaizumi, Kazuhiko
- Abstract
Zinc is an essential trace element for immune systems. Zinc deficiency is reported to decrease the number of lymphocytes and increase that of neutrophils. However, the effects of zinc deficiency on the number of white blood cells have not been fully elucidated. Therefore, the number of white blood cells during the dietary zinc deficiency for 26 days was studied in rats. Four-week-old male Sprague Dawley rats were divided into the control food (CON: Zn=53.5mg/kg food) group and the zinc deficient food (ZDF: Zn=1.9mg/kg food) group. Count analyses of total white blood cells, basophils, eosinophils, neutrophils, monocytes and lymphocytes were carried out by using a flow cytometry technique with emitting diode. The number of total white blood cells and monocytes was not changed in both groups. The number of basophils and eosinophils in ZDF group at the 14th day was significantly higher, respectively, than that in CON group. The number of neutrophils in ZDF group at the 21st and 26th day was significantly higher, respectively, than that in CON group. On the other hand, the number of lymphocytes in ZDF group at the 21st and 26th day was lower, respectively, than that in CON group. Thus dietary zinc deficiency increased the number of basophils, eosinophils and neutrophils and decreased the number of lymphocytes, suggesting the change in white blood cell distribution.
- Subjects
ZINC deficiency diseases; LEUCOCYTES; RATS; ZINC; BASOPHILS; EOSINOPHILS; NEUTROPHILS; LYMPHOCYTES
- Publication
FASEB Journal, 2007, Vol 21, Issue 5, pA719
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fasebj.21.5.a719-a