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- Title
Impacto del té verde epigalocatequina-3-galato en la expresión de HF1-a y mTORC2 en mujeres obesas: ¿efectos anticancerígenos y antiobesidad?
- Authors
Ferreira Nicoletti, Carolina; Pereira Delfino, Heitor Bernardes; Souza Pinhel, Marcela Augusta; Yumi Noronha, Natália; Caressato Pinhanelli, Vitor; Gomes Quinhoneiro, Driele Cristina; Parenti Oliveira, Bruno Affonso; Sergio Marchini, Júlio; Barbosa Nonino, Carla; Nicoletti, Carolina Ferreira; Delfino, Heitor Bernardes P; Pinhel, Marcela; Noronha, Natalia Y; Pinhanelli, Vitor Caressato; Quinhoneiro, Driele Cristina Gomes; de Oliveira, Bruno Affonso Parenti; Marchini, Julio Sergio; Nonino, Carla Barbosa
- Abstract
<bold>Introduction: </bold>Introduction: epigallocatechin-3-gallate (EGCG) is the most abundant catechin contained in green tea (Camellia sinensis) and has been associated with anti-obesity and anti-cancer effects, but the exact molecular mechanisms remain elusive. In this context, this study was designed to improve the understanding of the EGCG anti-obesity and anti-cancer action. Objectives: this study was designed to examine the effects of EGCG on the expression of genes involved in obesity and cancer pathways in the peripheral blood mononuclear cells of obese women. Material and methods: this longitudinal interventional study enrolled eleven women with severe obesity that were submitted to eight weeks of green tea (decaffeinated green tea capsules with 450.7 mg of EGCG, two capsules/day) supplementation (intervention group) and ten eutrophic women as a control group. Weight (kg), body mass index (BMI, kg/m2), fat mass (kg) and gene expression (qPCR method) were assessed before and after supplementation. HIF1-alpha (HIF1-α), phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) and rapamycin-insensitive companion of mTOR (RICTOR) were selected as potential targets. Results: after supplementation, body weight (114.9 ± 14.3 versus 115 ± 13.8 kg), body mass index (44.1 ± 3.7 versus 44.1 ± 3.9 kg/m2) and fat mass (47.6 ± 3.3 versus 47.3 ± 3.4 kg) did not change. EGCG upregulated the RICTOR and HIF1-α expression, however, did not modify PI3K expression. Conclusion: this study demonstrated that EGCG has a potential role to obesity and cancer related to obesity control and can be used not only for the purpose of weight loss, but also for the improvement of obesity-related comorbidities.
- Subjects
GREEN tea; EPIGALLOCATECHIN gallate; GENE expression; OBESITY treatment; CANCER treatment; BLOOD cells; BODY mass index; BODY weight
- Publication
Nutrición Hospitalaria, 2019, Vol 36, Issue 2, p315
- ISSN
0212-1611
- Publication type
journal article
- DOI
10.20960/nh.2216