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- Title
Development of a prospective cohort of HIV Exposed Sero-Negative (HESN) individuals in Jos Nigeria.
- Authors
Osawe, Sophia; Okpokoro, Evaezi; Datiri, Ruth; Choji, Grace; Okolo, Felicia; Datong, Pam; Abimiku, Alash'le
- Abstract
<bold>Background: </bold>HIV/AIDS continues to be a global health problem. With currently no cure, it is critical to get an effective vaccine to add to the arsenal of prevention and treatment tools. HIV Exposed Sero-Negative (HESN) individuals were enrolled and followed for 2 years.<bold>Methods: </bold>A prospective observational cohort study to enroll HESN volunteers and their partners was developed with a 2-year follow up. This was a vaccine preparedness study and designed as a Phase IIb trial. We provided counseling, lab testing and conducted medical examinations for all enrollees.<bold>Results: </bold>A total of 534 HESN were enrolled with 48 % (256) females and 52 % (278) males, a mean age of 37 ± 9 years. Three female HESN enrollees seroconverted giving this cohort a HIV incidence rate [95 % coefficient interval (CI)] of 3.2 (2.3-4.2) per 100,000 person-months of observation. Baseline analysis showed that female HESN are 24 % more likely to have their spouse consistently use condoms (RR 1.24; p = 0.04); 16 % more likely to have HIV+ partners with detectable viral load (RR 1.16, p = 0.03) and 28 % more likely that their HIV+ partners has a CD4 count less than 350cells/μl (RR 1.28, p = 0.03) when compared to male HESN.<bold>Conclusions: </bold>Our findings suggest that female HESN are more at risk of HIV acquisition due the low CD4 counts and detectable viral load among their HIV+ spouses. Moreover, we provide additional information on incidence and risk factors among naturally exposed persons, which might impact biomedical prevention research and immune responses to HIV vaccines.
- Subjects
NIGERIA; HIV prevention; HIV-positive persons; HIV; SEXUALLY transmitted disease vaccines; HIV infection transmission; DIAGNOSIS; SOCIAL history; DIAGNOSIS of HIV infections; HIV infection epidemiology; AIDS vaccines; CLINICAL trials; COMPARATIVE studies; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; RESEARCH; EVALUATION research; DISEASE incidence; HIV seronegativity
- Publication
BMC Infectious Diseases, 2016, Vol 16, p1
- ISSN
1471-2334
- Publication type
journal article
- DOI
10.1186/s12879-016-1649-1