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- Title
Effect of liver transplantation in combined hepatocellular and cholangiocellular carcinoma: a case series.
- Authors
Di Wu; Zhong-Yang Shen; Ya-Min Zhang; Jian Wang; Hong Zheng; Yong-Lin Deng; Cheng Pan; Wu, Di; Shen, Zhong-Yang; Zhang, Ya-Min; Wang, Jian; Zheng, Hong; Deng, Yong-Lin; Pan, Cheng
- Abstract
<bold>Background: </bold>Liver transplantation is a treatment option for combined hepatocellular and cholangiocellular carcinoma (cHCC-CC) but its prognostic significance remains unclear. The present study aimed to evaluate the therapeutic effects of liver transplantation on cHCC-CC and analyze the clinicopathological factors affecting prognosis.<bold>Methods: </bold>Retrospective analysis of the clinicopathological data of a case series of 21 patients with cHCC-CC who underwent orthotopic liver transplantation from April 2000 to April 2011 was performed. Cumulative survival rate and tumor-free survival rate were calculated using the Kaplan-Meier method followed by the log-rank test.<bold>Results: </bold>The operative survival rate of the 21 patients was 100%; the 30 day mortality was 4.8% (1/21) and 90-day mortality was 9.5% (2/21); 1-, 2-, 3-, and 5-year overall cumulative survival rates were 64%, 47%, 39%, and 39%, respectively; and the corresponding cumulative tumor-free survival rates were 64%, 37%, 30%, and 30%, respectively. Cumulative tumor diameter, lymph node metastasis, macroscopic portal vein tumor thrombus, and mixed states according to Allen typing were identified as the primary influencing factors of poor prognosis (all P < 0.05).<bold>Conclusion: </bold>Liver transplantation may be an effective therapeutic method for the treatment of cHCC-CC. Strict screening of potential liver transplantation candidates with cHCC-CC can help reduce the risks of tumor recurrence and metastasis.
- Subjects
LIVER transplantation; CHOLANGIOCARCINOMA; LIVER cancer; CANCER relapse; RETROSPECTIVE studies; PROGNOSIS; HEPATOCELLULAR carcinoma; LIVER tumors; LONGITUDINAL method; RESEARCH funding; TREATMENT effectiveness; DISEASE complications; BILE duct tumors; DIAGNOSIS; TUMOR treatment; THERAPEUTICS
- Publication
BMC Cancer, 2015, Vol 15, Issue 1, p1
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/s12885-015-1252-7