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- Title
Effects of glycine betaine on bone marrow death and intestinal damage by gamma rays and carbon ions.
- Authors
Monobe, M.; Hamano, N.; Sumi, M.; Mukai, K.; Moritake, T.; Anzai, K.; Uzawa, A.; Ando, K.
- Abstract
In this study, we investigated the effects of glycine betaine (GB) on bone marrow death and intestinal damage by gamma rays or carbon ions. C3H/He female mice received an i.p.-injection of GB before or after whole-body irradiation with gamma rays or 50 keV μm−1 carbon ions. The irradiated mice were observed to determine the mortality for 30 days after exposure. Mice were also killed at 3.5 days after the exposure to determine the intestinal damage. The numbers of crypts per transverse circumference were counted using a microscope. For the bone marrow death, GB (93 mg GB per mouse) significantly (p < 0.05) increased the percentage survival for both radiations. For the intestinal damage, GB (93 mg GB per mouse) significantly (p < 0.05) increased the crypt survival for gamma rays, but not for carbon ions. GB might be a potential protector against normal tissue damage as a side effect in radiotherapy.
- Subjects
GLYCINE; AMINO acid neurotransmitters; BETAINE; BONE marrow; GAMMA rays; ELECTROMAGNETIC waves; CARBON
- Publication
Radiation Protection Dosimetry, 2006, Vol 122, Issue 1-4, p494
- ISSN
0144-8420
- Publication type
Article
- DOI
10.1093/rpd/ncl390