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- Title
Cholinergic Autonomic Dysfunction in Veterans with Gulf War Illness.
- Authors
Latov, Norman
- Abstract
In a nested case-control study, the authors evaluated autonomic symptoms and functions in a representative sample of veterans meeting validated case definition of Gulf War illness, and compared these to autonomic symptoms and functions in a control population consisting of a representative sample of randomly selected subjects from a U.S. military health survey. Validated outcome measures included the Autonomic Symptoms Profile Questionnaire, Composite Autonomic Severity Score, heart rate variability in a 24-hour electrocardiogram, and Quantitative Sudomotor Axon Reflex Test (QSART). The study found that veterans with the Gulf War illness had a significant increase of autonomic symptoms compared to controls including in orthostatic intolerance, secretomotor symptoms, upper gastrointestinal and urinary dysfunction, autonomic diarrhea or constipation, sleep disturbances, pupilomotor and vasomotor abnormalities, and erectile dysfunction. These were most consistent with cholinergic autonomic dysfunction. The autonomic symptoms correlated with objective measures of impairment in the Quantitative Sudomotor Axon Reflex Test (QSART) and high frequency of heart rate variability in a 24-hour electrocardiogram. The accompanying editorial discusses the potential role of stress in the development of autonomic dysfunction.
- Subjects
DIAGNOSIS of autonomic nervous system diseases; PERIPHERAL neuropathy diagnosis; HEART rate monitoring; VETERANS; NEUROLOGY; SURVEYS; WAR
- Publication
Neurology Alert, 2013, Vol 31, Issue 9, p1
- ISSN
0741-4234
- Publication type
Article