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- Title
Multimodal assessment of disease activity in glioblastoma: A single center experience.
- Authors
Tinchon, Alexander; Marhold, Franz; Calabek-Wohinz, Bernadette; Hainz, Katharina; Tesar-Pelz, Martina; Minear, Gregory; Freydl, Elisabeth; Blauensteiner, Katrin; Heinz, Gertraud; Oberndorfer, Stefan
- Abstract
Summary: Background: Assessment of disease activity in glioblastoma (GBM) can be challenging due to several clinical and radiological pitfalls. Besides MRI, FET-PET and neurocognitive assessment (NA) are used in several neuro-oncological centers in order to improve the specificity of response assessment. We performed a retrospective study to investigate whether the assessment by RANO (Response Assessment in NeuroOncology) corresponds to FET-PET imaging and NA results. Moreover, the concordance of RANO with a final recommendation of an interdisciplinary neuro-oncological tumor board recommendation (TBR) was analyzed. Methods: We enrolled 25 consecutive patients with newly diagnosed histologically confirmed GBM in a pilot study, accounting for 81 multimodal test results. All patients were selected after undergoing consecutive follow-up comprising MRI, FET-PET, and NA with a subsequent TBR. Results were analyzed for correlations between RANO, FET-PET and NA. An additional consistency analysis was performed to elucidate the impact of RANO on decision making. Results: A highly statistically significant correlation was found between RANO and FET-PET and NA results (all P < 0.01); however, 26% of follow-up tests exhibited inconsistent results in multimodal assessment, among which RANO was only 48% in accordance with the final TBR. The concordance of NA and FET-PET with the final TBR was 67% and 86%, respectively. Conclusion: The RANO proved its value in the context of multimodal assessment of disease activity in GBM; however, because the implementation of multimodal assessment showed a considerably high percentage of inconsistent results, further studies are required to investigate the relationship between different assessment techniques, in addition to their overall significance to response rating.
- Subjects
GLIOBLASTOMA multiforme; DIAGNOSIS; DECISION making; MAGNETIC resonance imaging
- Publication
Wiener Klinische Wochenschrift, 2021, Vol 133, Issue 21/22, p1148
- ISSN
0043-5325
- Publication type
Article
- DOI
10.1007/s00508-021-01859-2