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- Title
Free radical reactions in atherosclerosis; An EPR spectrometry study.
- Authors
Taiwo, F. A.; Powers, H. J.; Nakano, E.; Griffiths, H. R.; Nugent, D. F.
- Abstract
The copper catalysed oxidation of homocysteine has been studied by electron paramagnetic resonance (EPR) spectroscopy and spin trapping techniques to determine the nature of free radical species formed under varying experimental conditions. Three radicals; thiyl, alkyl and hydroxyl were detected with hydroxyl being predominant. A reaction mechanism is proposed involving Fenton chemistry. Inclusion of catalase to test for intermediate generation of hydrogen peroxide showed a marked reduction in amount of hydroxyl radical generated. In contrast, the addition of superoxide dismutase showed no significant effect on the level of hydroxyl radical formed. Enhanced radical formation was observed at higher levels of oxygen, an effect which has consequences for differential oxygen levels in arterial and venous systems. Implications are drawn for a higher incidence of atherosclerotic plaque formation in arteries versus veins.
- Subjects
ATHEROSCLEROSIS; FREE radical reactions; ELECTRON paramagnetic resonance spectroscopy; HYDROXYL group; SUPEROXIDE dismutase; HYDROGEN peroxide
- Publication
Spectroscopy: An International Journal, 2006, Vol 20, Issue 2, p67
- ISSN
0712-4813
- Publication type
Article
- DOI
10.1155/2006/474183