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- Title
Denitration of L-type calcium channel
- Authors
Kang, Minho; Akbarali, Hamid I.
- Abstract
Abstract: Tyrosine nitration results in altered function of selective proteins, including human smooth muscle L-type calcium channel, hCav1.2b. We report here that Cav1.2 is also subject to “denitration”. Cell lysates from activated macrophage-like cell line, RAW264.7 cells, reversed peroxynitrite-induced nitration of the carboxy terminus of Cav1.2 in a 1D gel assay. Tyrosine phosphorylation of the calcium channel by c-src kinase was blocked by nitration but reversed by pretreatment with RAW264.7 cell lysates. These findings indicate that denitration may be a physiological mechanism to restore cellular excitability during inflammation.
- Subjects
TYROSINE; NITRATION; PROTEINS; CALCIUM channels; MACROPHAGES; PHOSPHORYLATION; INFLAMMATION
- Publication
FEBS Letters, 2008, Vol 582, Issue 20, p3033
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2008.07.042