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- Title
The Chromatin Assembly Factor 1 Promotes Rad51-Dependent Template Switches at Replication Forks by Counteracting D-Loop Disassembly by the RecQ-Type Helicase Rqh1.
- Authors
Pietrobon, Violena; Fréon, Karine; Hardy, Julien; Costes, Audrey; Iraqui, Ismail; Ochsenbein, Françoise; Lambert, Sarah A.E.
- Abstract
: A molecular switch for times of replication stress - Chromatin Assembly Factor 1 helps to protect DNA during recombination-mediated template-switching, favoring the rescue of stalled replication forks by both beneficial and detrimental homologous recombination events.
- Subjects
DNA replication; DNA repair; CHROMATIN; CANCER cells; BLOOM syndrome; DNA synthesis
- Publication
PLoS Biology, 2014, Vol 12, Issue 10, p1
- ISSN
1544-9173
- Publication type
Article
- DOI
10.1371/journal.pbio.1001968