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- Title
Comparison of paclitaxel-cetuximab chemotherapy versus metronomic chemotherapy consisting of methotrexate and celecoxib as palliative chemotherapy in head and neck cancers.
- Authors
Patil, V. M.; Noronha, V.; Joshi, A.; Agarwala, V.; Muddu, V.; Ramaswamy, A.; Chandrasekharan, A.; Dhumal, S.; Juvekar, S.; Arya, A.; Bhattacharjee, A.; Prabhash, K.
- Abstract
<bold>Background: </bold>The present match pair analysis was planned to compare the efficacy of cetuximab-paclitaxel-based chemotherapy versus metronomic therapy.<bold>Materials and Methods: </bold>Sixty patients with metastatic/recurrent head and neck squamous cell cancer treated with weekly paclitaxel (80 mg/m2) and cetuximab were matched with sixty patients treated with oral metronomic chemotherapy consisting of methotrexate and celecoxib. The progression-free survival (PFS) and overall survival (OS) between the cohorts were compared using log-rank test. Cox proportional regression model was used to identify independent factors affecting PFS and OS.<bold>Results: </bold>The median OS was 191 days (95% confidence interval [CI]: 122.2-259.8 days) in metronomic cohort and 256 days (95% CI 177.0-334.9 days) in cetuximab cohort (hazard ratio: 0.58, 95% CI: 0.35-0.95, P = 0.031). On Cox proportional hazard model, Eastern Cooperative Oncology Group Performance Status (0-1 vs. 2) and therapy (cetuximab versus metronomic) had a statistically significant impact on OS.<bold>Conclusion: </bold>Cetuximab-based chemotherapy leads to a significant improvement in OS in the match pair analysis in comparison to metronomic chemotherapy.
- Subjects
PACLITAXEL; CETUXIMAB; CANCER chemotherapy; CELECOXIB; METHOTREXATE; ANTINEOPLASTIC agents; COMPARATIVE studies; HEAD tumors; RESEARCH methodology; MEDICAL cooperation; NECK tumors; RESEARCH; EVALUATION research
- Publication
Indian Journal of Cancer, 2017, Vol 54, Issue 1, p20
- ISSN
0019-509X
- Publication type
journal article
- DOI
10.4103/ijc.IJC_160_17