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- Title
Malformaciones menores y otras anormalidades morfológicas en serie de necropsias fetales y perinatales en Bogotá.
- Authors
Olaya C., Mercedes; Barragán-Osorio, Paola; Giraldo, Gustavo; Castro, Jennifer; Vanegas, Ana M.; Beltrán, Derly; Salazar, Ana J.; Céspedes, Víctor H.; Bernal, Jaime E.
- Abstract
BACKGROUND: During autopsy morphological abnormalities should be classified in major or minor malformations, disruptions, sequences, deformities, trauma, changes attributable to fixation, intrauterine death, or manipulation, among others. Appropriate counseling in genetics and obstetrics is going to depend on this approach. In the current study we want to know the frequencies of morphological changes and their association with clinical presentations. MATERIALS AND METHODS: Observational descriptive study carried out on consecutive perinatal autopsies product from natural deaths in which morphological changes were classified. RESULTS: In 87 perinatal autopsies a female predominance was observed, as well as a major occurrence in mothers between 18 and 35 years and in individuals with severe maceration. The most frequent major malformations were found in the face, abdomen and skeleton. Among minor malformations, the skeletal ones were the most predominant (clinodactyly (36.75%), brachydactyly (23.52%), sandal gap (14.7%)); followed by facial anomalies (depressed nasal bridge (58.24%), glossoptosis (16.64%), hypertelorism (8.32%); and, neck defects (winged neck (31.25%), short (37.5%), elongated (18.75%). Among disruptions, amniotic bands were found covering large segments (2.29%). The most frequent deformity was equinovarus foot (6.89%). CONCLUSIONS: In the present interdisciplinary observation focused on perinatal deaths, a relation between cromosomopathies and severe maceration was identified. The most frequent morphological features corresponded to minor malformations. Any change in the morphology of a newborn or a fetus may be the key to the main diagnosis. For this reason, morphological changes must to be recognized and distinguished among them to guide the reproductive future of the families, provide genetic counseling and achieve a positive impact on public health.
- Subjects
FETAL death; GENETIC counseling; GENETICS; PERINATAL death; NATURAL products; AUTOPSY; INTERDISCIPLINARY approach to knowledge
- Publication
Patologia Revista Latinoamericana, 2019, Vol 57, p1
- ISSN
0185-4305
- Publication type
Article
- DOI
10.24245/patrl.v57id.2932