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- Title
First in-human evaluation of [1-<sup>13</sup>C]pyruvate in D<sub>2</sub>O for hyperpolarized MRI of the brain: A safety and feasibility study.
- Authors
Deh, Kofi; Guannan Zhang; Park, Angela Hijin; Cunningham, Charles H.; Bragagnolo, Nadia D.; Lyashchenko, Serge; Ahmmed, Shake; Leftin, Avigdor; Coffee, Elizabeth; Hricak, Hedvig; Miloushev, Vesselin; Mayerhoefer, Marius; Keshari, Kayvan R.
- Abstract
Purpose: To investigate the safety and value of hyperpolarized (HP) MRI of [1-13C]pyruvate in healthy volunteers using deuterium oxide (D2O) as a solvent. Methods: Healthy volunteers (n=5), were injected with HP [1-13C]pyruvate dissolved in D2O and imaged with a metabolite-specific 3D dual-echo dynamic EPI sequence at 3T at one site (Site 1). Volunteers were monitored following the procedure to assess safety. Image characteristics, including SNR, were compared to data acquired in a separate cohort using water as a solvent (n=5) at another site (Site 2). The apparent spin-lattice relaxation time (T1) of [1-13C]pyruvate was determined both in vitro and in vivo from a mono-exponential fit to the image intensity at each time point of our dynamic data. Results: All volunteers completed the study safely and reported no adverse effects. The use of D2O increased the T1 of [1-13C]pyruvate from 66.5±1.6 s to 92.1±5.1 s in vitro, which resulted in an increase in signal by a factor of 1.46±0.03 at the time of injection (90 s after dissolution). The use of D2O also increased the apparent relaxation time of [1-13C]pyruvate by a factor of 1.4±0.2 in vivo. After adjusting for inter-site SNR differences, the use of D2O was shown to increase image SNR by a factor of 2.6±0.2 in humans. Conclusions: HP [1-13C]pyruvate in D2O is safe for human imaging and provides an increase in T1 and SNR that may improve image quality.
- Subjects
PYRUVATES; DEUTERIUM oxide; SPIN-lattice relaxation; MAGNETIC resonance imaging; FEASIBILITY studies
- Publication
Magnetic Resonance in Medicine, 2024, Vol 91, Issue 6, p2559
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.30002