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- Title
NT-pro BNP level at dialysis initiation is a useful biomarker for predicting hospitalization for ischemic heart disease.
- Authors
Shimohata, Homare; Usui, Joichi; Tawara-Iida, Takashi; Ebihara, Itaru; Ishizu, Takashi; Maeda, Yoshitaka; Kobayashi, Hiroaki; Numajiri, Daichi; Kaneshige, Ayaka; Sega, Masatoshi; Yamashita, Marina; Ohgi, Kentaro; Maruyama, Hiroshi; Takayasu, Mamiko; Hirayama, Kouichi; Kobayashi, Masaki; Yamagata, Kunihiro
- Abstract
Background: Patients with end-stage kidney disease (ESKD) are at high risk of cardiovascular disease including stroke, heart failure, and ischemic heart disease (IHD). To prevent the occurrence and progression of CVD, a reliable prognostic cardiac biomarker is essential. We investigated the prognostic value of NT-proBNP for each incident type of CVD. Methods: Male patients from the Ibaraki Dialysis Initiation Cohort (iDIC) study with preserved serum samples from dialysis initiation day (n = 212) were analyzed. Patients were classified into four groups according to quartiles of baseline NT-pro BNP levels. The relationship between NT-proBNP levels at the initiation of dialysis and the subsequent incidence of hospitalization events due to IHD, heart failure, and stroke was analyzed. Results: The incidence rate for hospitalization due to IHD was significantly higher in the highest NT-proBNP category (Log rank p = 0.008); those of stroke and heart failure showed no significant differences among quartiles. Cox proportional hazards regression analysis revealed that serum NT-proBNT was the only prognostic factor for hospitalization for IHD after adjustment by major known IHD risk factors. (HR, 1.008; 95% confidence interval, 1.002–1.014; p = 0.01) The ROC curve analysis for the incidence of hospitalization due to IHD showed that NT-proBNP had an area under the curve (AUC) of 0.759 (95% CI 0.622–0.897; p = 0.004) at a cut-off value of 956.6 pg/mL. Conclusion: NT-proBNP measurement at the initiation of dialysis therapy is useful to predict later hospitalization for IHD. Trial registration: UMIN000010806.
- Subjects
MYOCARDIAL ischemia; CORONARY disease; CHRONIC kidney failure; DIALYSIS (Chemistry); HEMODIALYSIS
- Publication
Clinical & Experimental Nephrology, 2024, Vol 28, Issue 5, p457
- ISSN
1342-1751
- Publication type
Article
- DOI
10.1007/s10157-023-02442-x