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- Title
Genetische Risikovarianten beim Parkinson-Syndrom und anderen Bewegungsstörungen.
- Authors
Brockmann, K.; Lohmann, K.
- Abstract
Movement disorders are often genetically complex with genetic risk factors playing a major role. For example, monogenic causes of Parkinson's disease (PD) can be found in only 2-5% of patients who often have an early onset (<40 years). In the majority of patients, common genetic variants seem to contribute to the disease risk. To date, 24 genetic risk factors have been identified. For restless legs syndrome (RLS), six different risk variants have been reported but no monogenic cause is known yet. For the genetic risk factors of essential tremor and dystonia, which are less well studied, only five and two candidate variants, respectively, have been described but their roles still require independent confirmation. In this review, we provide an overview on the involved genes, their function, and discuss possible, disease mechanism-driven therapies.
- Publication
Der Nervenarzt, 2017, Vol 88, Issue 7, p713
- ISSN
0028-2804
- Publication type
Article
- DOI
10.1007/s00115-017-0348-5