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- Title
Programmed cell death protein 1 expression is an independent prognostic factor in gastric cancer after curative resection.
- Authors
Eto, Shohei; Yoshikawa, Kozo; Nishi, Masaaki; Higashijima, Jun; Tokunaga, Takuya; Nakao, Toshihiro; Kashihara, Hideya; Takasu, Chie; Iwata, Takashi; Shimada, Mitsuo
- Abstract
Background: Programmed cell death protein 1 (PD-1) and its ligand PD-L1 downregulate T cell activation and are related to immune tolerance. The aim of this study was to clarify the significance of PD-1 and PD-L1 expression and to analyze the relationships among PD-1, PD-L1, and Foxp3 expression in gastric cancer. Methods: A total of 105 patients who underwent curative gastrectomy for stage II/III gastric cancer were included in this study. PD-1, PD-L1, and Foxp3 expression were examined by immunohistochemistry and related to prognostic factors by univariate and multivariate analyses. Results: PD-1 expression was correlated with both PD-L1 and Foxp3 expression. Disease-free survival (DFS) was significantly poorer in PD-1-positive patients than in PD-1-negative patients (3-year DFS, 36.1 % vs. 64.7 %, respectively; p < 0.05). Overall survival also tended to be poorer in PD-L1-positive patients than in PD-L1-negative patients. Univariate analysis identified sex, T factor, lymphatic invasion, and PD-1 positivity as significant predictors of poor DFS. Multivariate analysis confirmed male sex, lymphatic invasion, and positive PD-1 expression as independent prognostic indicators. Conclusions: PD-1 expression is associated with a poor prognosis and is correlated with PD-L1 and Foxp3 expression in patients with gastric cancer.
- Subjects
STOMACH cancer; PROGRAMMED cell death 1 receptors; SCURFIN (Protein); GASTRECTOMY; CANCER remission; APOPTOSIS; PROGRESSION-free survival; PROGNOSIS
- Publication
Gastric Cancer, 2016, Vol 19, Issue 2, p466
- ISSN
1436-3291
- Publication type
Article
- DOI
10.1007/s10120-015-0519-7