We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Persistent Tissue Kinetics and Redistribution of Nanoparticles, Quantum Dot 705, in Mice: ICP-MS Quantitative Assessment.
- Authors
Yang, Raymond S. H.; Chang, Louis W.; Jui-Pin Wu; Ming-Hsien Tsai; Hsiu-Jen Wang; Yu-Chun Kuo; Teng-Kuang Yeh; Chung Shi Yang; Pinpin Lin
- Abstract
BACKGROUND: Quantum dots (QDs) are autofluorescent semiconductor nanocrystals that can be used for in viva biomedical imaging. However, we know little about their in viva disposition and health consequences. OBJECTIVES: We assessed the tissue disposition and pharmacokinetics of QD705 in mice. METHODS: We determined quantitatively the blood and tissue kinetics of QD705 in mice after single intravenous (iv) injection at the dose of 40 pmol for up to 28 days. Inductively coupled plasmamass spectrometry (ICP-MS) measurement of cadmium was the primary method of quantification of QD705. Fluorescence light microscopy revealed the localization of QD705 in tissues. RESULTS: Plasma half-life of QD705 in mice was short (18.5 hr), but ICP-MS analyses revealed QD705 persisted and even continued to increase in the spleen, liver, and kidney 28 days after an iv dose. Considerable time-dependent redistribution from body mass to liver and kidney was apparent between 1 and 28 days postdosing. The recoveries at both time points were near 100%; all QD705s reside in the body. Neither fecal nor urinary excretion of QD705 was detected appreciably in 28 days postdosing. Fluorescence microscopy demonstrated deposition of QD705 in the liver, spleen, and kidneys. CONCLUSION: Judging from the continued increase in the liver (29-42% of the administered dose), kidney (1.5-9.2%), and spleen (4.8-5.2%) between 1 and 28 days without any appreciable excretion, QD705 has a very long half-life, potentially weeks or even months, in the body and its health consequences deserve serious consideration.
- Subjects
QUANTUM dots; SEMICONDUCTOR nanocrystals; MICE; FLUORESCENCE microscopy; INDUCTIVELY coupled plasma mass spectrometry; CADMIUM; EXCRETORY organs
- Publication
Environmental Health Perspectives, 2007, Vol 115, Issue 9, p1339
- ISSN
0091-6765
- Publication type
Article
- DOI
10.1289/ehp.10290