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- Title
No effects of COVID-19 on the development of type 1 diabetes autoimmunity and no evidence of an increased frequency of SARS-CoV-2 antibodies in newly diagnosed type 1 diabetes patients relative to healthy subjects.
- Authors
Tiberti, Claudio; Nenna, Raffaella; Tromba, Valeria; Filardi, Tiziana; Petrarca, Laura; Silvestri, Francesca; Fassino, Valeria; Montuori, Monica; Mancino, Enrica; Lenzi, Andrea; Midulla, Fabio; Costantino, Francesco; Morano, Susanna
- Abstract
Aims: To evaluate the relationship between SARS-CoV-2 infection and autoimmunity in type 1 diabetes (T1D) and SARS-CoV-2 antibodies frequency at diagnosis of T1D during pandemic. Methods: The presence of T1D-specific autoimmunity was evaluated in a cohort of 99 children and adolescents without diabetes that contracted SARS-CoV-2 infection. Moreover, the frequency of IgM- and IgG-SARS-CoV-2 antibodies was evaluated in 41 newly diagnosed T1D patients not yet vaccinated against SARS-CoV-2 disease, collected during the pandemic, compared to healthy subjects (CTRL). Results: None of the 99 patients that contracted SARS-CoV-2 infection during the pandemic period was found positive for T1D autoantibodies. The frequency of SARS-CoV-2 antibodies was not significantly different in patients newly diagnosed with T1D (12.2%), compared with CTRL (8.4%). Among SARS-CoV-2 antibody positive T1D patients, 80% were target of diabetes autoantibodies and 60% had another concomitant autoimmune disease. Among the CTRL subjects positive for SARS-CoV-2Abs (n = 10), none was found positive for T1D autoantibodies. Conclusions: The results of the present study do not confirm, at least in the short term, a role of COVID-19 as a potential trigger of T1D autoimmunity and do not provide evidence of an increased frequency of SARS-CoV-2 antibodies in newly diagnosed T1D patients in comparison with healthy population.
- Subjects
TYPE 1 diabetes; SARS-CoV-2; PEOPLE with diabetes; AUTOANTIBODIES; IMMUNOGLOBULINS; AUTOIMMUNITY; COVID-19
- Publication
Acta Diabetologica, 2023, Vol 60, Issue 10, p1301
- ISSN
0940-5429
- Publication type
Article
- DOI
10.1007/s00592-023-02103-1