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- Title
Mast cells in canine cutaneous hemangioma, hemangiosarcoma and mammary tumors.
- Authors
Woldemeskel, Moges; Rajeev, Sreekumari
- Abstract
Mast cell count (MCC) in 45 dogs with cutaneous hemangioma (HA, n=12), hemangiosarcoma (HSA, n=12), mammary adenoma (AD, n=9) and mammary adenocarcinoma (AC, n=12) was made using Toluidine blue stained sections. Antibodies against endothelial cell markers, Factor VIII and VEGF were used to visualize and determine the hot spot micro-vessel density (MVD). Total MCC and MCC along the invasive edges were significantly higher (p<0.001) in canine mammary AC than in AD. The total MCC did not significantly differ (p>0.05), in HSAs (8.6±3.3) than in HAs (5.5±2.8). There is a positive correlation (r=0.14) between the hot spot MCC and MVD in mammary AC, although not significant (p=0.3172), indicating that mast cells are associated with angiogenesis in canine mammary AC. This study suggests that mast cells may play an important role in neovascularization of canine cutaneous vascular and mammary neoplasms. Detailed studies encompassing correlation of MCC and MVD with clinical outcomes and prognosis in these neoplasms are recommended.
- Subjects
MAST cells; HEMANGIOMAS; ANGIOSARCOMA; MAMMARY gland tumors; VASCULAR endothelial growth factors; DOGS
- Publication
Veterinary Research Communications, 2010, Vol 34, Issue 2, p153
- ISSN
0165-7380
- Publication type
Article
- DOI
10.1007/s11259-010-9341-1