We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Distribution of Methyl Sulfone Metabolites of Polychlorinated Biphenyls and p,p'-DDE in Human Tissues.
- Authors
Shaogang Chu; Covaci, Adrian; Jacobs, Werner; Haraguchi, Koichi; Schepens, Paul
- Abstract
We determined methylsulfonyl metabolites of chlorinated biphenyls (MeSO[sub 2]-CBs) and 1,1-bis(4chlorophenyl)-2,2-dichloroethene (p,p'-DDE) in human adipose, liver, brain, and lung tissues obtained from 11 Belgian individuals (9-62 years of age). The total concentration of MeSO[sub 2]-CBs (lipid weight basis) decreased in the following order: liver (mean, 9.30 ng/g; range, 1.68-27.03 ng/g lipid) > lung [mean, 2.72 ng/g; range, not detected (ND) to 11.54 ng/g lipid] > adipose tissue (mean, 1.57 ng/g; range, 0.33-4.33 ng/g lipid) > brain (mean, 0.24 ng/g; range, ND-0.56 ng/g lipid). The profiles of MeSO[sub 2]-CBs and MeSO[sub 2]-DDE in each tissue were similar for all 11 subjects. In adipose, brain, and lung tissues, 4'-MeSO[sub 2]-CB87, 4'-MeSO[sub 2]-CB101, and 3-MeSO[sub 2]-CB149 (except brain) occurred at higher concentrations than did other MeSO[sub 2]-CBs. However, 3'-MeSO[sub 2]CB132 was by far the most abundant congener in liver, contributing on average to approximately 60% of the sum of MeSO[sub 2]-CBs. The concentrations of 3-MeSO[sub 2]-DDE in different tissues were at the same or lower levels than the total concentrations of MeSO[sub 2]-CBs. This study suggests that the distribution patterns of MeSO[sub 2]-CBs and MeSO[sub 2]-DDE in humans differ between liver and other tissues. Moreover, these profiles differ from those found in other mammals, such as polar bears, porpoises, and otters.
- Subjects
BELGIUM; METHANESULFONATES; TISSUES
- Publication
Environmental Health Perspectives, 2003, Vol 111, Issue 9, p1222
- ISSN
0091-6765
- Publication type
Article
- DOI
10.1289/ehp.6141