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- Title
Hepatoprotective Effects of Coenzyme Q10 against Amoxiclav-induced Hepatotoxicity in the Rat Model.
- Authors
F. A., Ghafil; Z., Abed al-kareem; S., Abdulredha Majeed; N. D., Aziz; S. M. H., Rasheed
- Abstract
Aims Amoxiclav antibiotic is a commonly prescribed medication for many medical situations. One of the side effects of amoxiclav is hepatotoxicity. Coenzyme Q10, as a potent anti-oxidant, can play a beneficial role in reducing various drug-induced hepatotoxicity. The present study aimed to evaluate the hepatoprotective effects of coenzyme Q10 against amoxiclav-induced hepatotoxicity in the rat model. Materials & Methods 24 male albino rats weighing 150-250g were randomly divided into four groups of six animals. The control group was given normal saline; the amoxiclav group was given 30mg/Kg/day of amoxiclav orally for 30 days; In the amoxiclav and CoQlO group, each animal was given orally 30mg/Kg of amoxiclav, and 100mg/Kg CoQlO orally daily for 30 days; In CoQlO group, each rat was given 100mg/Kg CoQlO orally daily for 30 days. Atthe end of the experiment, the animals were anesthetized and then scarified to assess the serum liver enzymes, as well as liver tissue samples were obtained for histopathological study. Finding; Liver function parameters were significantly elevated in the animal group treated with amoxiclav, and hepatocellular necrosis and congestion were observed in histopathological examination. Concomitant treatment with CoQlO and amoxiclav significantly reduced the liver enzymes and improved hepatocellular congestion and inflammation. Conclusion CoQlO is a potent anti-inflammatory and anti-oxidant agent that can be used to reduce amoxiclav-induced hepatotoxicity.
- Subjects
IRAQ; TISSUE analysis; CLAVULANIC acid; LIVER function tests; COMBINATION drug therapy; IN vivo studies; LIVER; ONE-way analysis of variance; UBIQUINONES; HEPATOTOXICOLOGY; TREATMENT effectiveness; RATS; DESCRIPTIVE statistics; STATISTICAL sampling; DATA analysis software; AMOXICILLIN; PHYSIOLOGIC salines; EVALUATION
- Publication
Iranian Journal of War & Public Health, 2023, Vol 15, Issue 1, p77
- ISSN
2008-2622
- Publication type
Article
- DOI
10.58209/ijwph.15.1.77