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- Title
Evaluation of Amino Acids Profile as Non-Invasive Biomarkers of Hepatocellular Carcinoma in Egyptians.
- Authors
Ghanem, Samar Ebrahim; Abdel-Samiee, Mohamed; El-Said, Hala; Youssef, Mohamed I.; ElZohry, Hassan Ahmed; Abdelsameea, Eman; Moaz, Inas; Abdelwahab, Sayed F.; Elaskary, Shymaa A.; Zaher, Eman Mohammed; Helal, Marwa Lotfy
- Abstract
Background: Hepatocellular carcinoma (HCC) is the most dangerous complication of chronic liver disease. It is a multifactorial complicated disease. Hepatitis C and hepatitis B viruses (HCV and HBV, respectively) represent the main causes of HCC in Egypt. Early diagnosis is very important to aid in early intervention. Objectives: The goal of this research is to evaluate the metabolic role of different amino acids as non-invasive biomarkers over the course of HCC. Methods: This study included 302 participants with 97 diagnosed, untreated HCC patients, 81 chronic HCV patients, 56 chronic HBV patients, 18 co-infected patients, and a control group of 50 normal age and gender-matched individuals. All participants provided complete medical histories and underwent complete clinical examinations, abdominal ultrasonography and/or computed tomography, routine laboratory investigations, estimation of serum α-fetoprotein, and determination of amino acid levels using ultra-performance liquid chromatography (UPLC MS/MS). Results: This work revealed a decline in branched chain amino acids (BCAA) and increase in aromatic amino acids (AAA) among infected groups (HCC, HBV, HCV, and co-infected patients) compared to control subjects and a marked change in Fisher's and the BCAAs/tyrosine molar concentration ratios (BTR) between controls and infected groups. Conclusion: Different amino acids could be used as non-invasive markers to discriminate and follow chronic hepatitis patients to predict the course of HCC.
- Publication
Tropical Medicine & Infectious Disease, 2022, Vol 7, Issue 12, p437
- ISSN
2414-6366
- Publication type
Article
- DOI
10.3390/tropicalmed7120437