We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Tumor Recurrence and Graft Survival in Renal Transplant Recipients with a History of Pretransplant Malignancy: A Matched Pair Analysis.
- Authors
Becker, Felix; Mehdorn, Anne-Sophie; Getsopulos, Vasilios; Schütte-Nütgen, Katharina; Reuter, Stefan; Suwelack, Barbara; Pascher, Andreas; Brockmann, Jens G.; Bahde, Ralf
- Abstract
Organ scarcity demands critical decision-making regarding eligible transplant candidates and graft allocation to ensure best benefit from renal transplantation (RTx). Among the controversial relative contraindications is a history of pretransplant malignancy (PTM). While oncological outcomes of PTM-RTx recipients are well described, data on graft-specific outcome are scarce. A retrospective double case control matched pair analysis (60 months follow-up) was carried out and RTx-recipients were stratified for history of PTM. First, PTM-RTx recipients were matched according to age, sex and duration of immunosuppressive therapy. Next, PTM-RTx recipients were matched 1:1 for age, sex and cause of end-stage renal disease. Five-year patient and graft survival as well as oncological outcomes were analyzed. A total of 65 PTM-RTx recipients were identified. Post-RTx recurrence rate was 5%, while 20% developed second de novo malignancy, comparable to 14% in the control group. PTM-RTx recipients had a noticeable lower five-year death-censored as well as overall graft survival and Cox proportional hazard modeling showed a correlation between PTM and inferior graft survival. Although underlying reasons remain not fully understood, this study is the first to show inferior graft survival in PTM-RTx recipients and advocates necessity to focus on more meticulous graft monitoring in PTM recipients in addition to heightened surveillance for cancer recurrence.
- Subjects
GRAFT survival; DISEASE relapse; KIDNEY transplantation; PROPORTIONAL hazards models; CHRONIC kidney failure; CANCER relapse
- Publication
Journal of Clinical Medicine, 2021, Vol 10, Issue 11, p2349
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm10112349