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- Title
Towards a Prophylactic Vaccine for the Prevention of HCMV Infection.
- Authors
Ligat, Gaëtan; Alain, Sophie; Hantz, Sébastien
- Abstract
Human cytomegalovirus (HCMV) or human herpesvirus 5, is a ubiquitous human herpesvirus, which can cause severe disease in immunocompromised patients (AIDS patients and solid organ transplant or hematopoietic stem cell transplant recipients). Other mRNA-based vaccines, developed by Moderna, Inc encoded HCMV gB and pentameric complex (PC) or the major HCMV T-cell antigen pp65. A HCMV mRNA vaccine was first developed by Novartis (now GSK) and contained gB and a pp65-IE1 fusion construct [[14]]. The quick development of mRNA-based vaccines to protect against novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the COVID-19 pandemic led to the development of mRNA-based vaccines both for oncology and infectious diseases, including HCMV infections.
- Subjects
INFECTION prevention; CONGENITAL disorders; HEMATOPOIETIC stem cell transplantation; VACCINES; MEDICAL virology
- Publication
Vaccines, 2021, Vol 9, Issue 9, p968
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines9090968