We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Familial Recurrence Risk of Tic Disorders and Obsessive-Compulsive Disorder: A Population-Based Cohort Study.
- Authors
GRICE, Dorothy E.
- Abstract
Objective: This study determines sibling and parent-offspring recurrence risk for tic disorders (TD) and obsessive-compulsive disorder (OCD) with high precision and minimal bias, utilizing the Danish registry system. Methods: We accessed relevant Danish registries to identify all individuals with TD or OCD. Recurrence risk was determined using Kaplan-Meier methods. Relative recurrence risk (likelihood that an individual with an oldest sibling or parent with TD or OCD is affected by the disorder compared to an individual without an affected sibling or parent) was calculated using Cox regression. Results: Of 1,741,271 individuals born from 1980-2007, 5596 had a TD diagnosis and 6,191 had an OCD diagnosis. Prevalence was 0.42% for TD and 0.84% for OCD. Individuals with an oldest sibling with TD were 18 times more likely to be diagnosed with TD, while those with an oldest sibling with OCD were 5 times more likely to be diagnosed with OCD. Individuals whose parent had TD were 61 times more likely to have TD; those whose parent had OCD were 6 times more likely to have OCD. Cross-disorder risk was also significant, though driven in part by individuals who had both diagnoses. Conclusions: Our population-based recurrence risk estimates demonstrate high TD and OCD sibling and parent-offspring recurrence risk, and provide an important framework for affected families. Future work using the Danish registries will provide additional novel insights into the etiology of these disorders.
- Subjects
TIC disorders; KAPLAN-Meier estimator; SIBLINGS; DEMOGRAPHY; VITAL statistics
- Publication
Japanese Journal of Child & Adolescent Psychiatry, 2015, Vol 56, Issue 3, p297
- ISSN
0289-0968
- Publication type
Article