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- Title
Mechanism and effects of fructose diphosphate on anti-hypoxia fatigue and learning memory ability.
- Authors
Liu, Chunna; Shao, Chunhua; Du, Qi; He, Chaoran; Sun, Xinyuan; Lou, Anqi; Ma, Zhijie; Yu, Junxian
- Abstract
This study aims to investigate the mechanisms through which fructose diphosphate (FDP) causes anti-hypoxia and anti-fatigue effects and improves learning and memory. Mice were divided into three groups: low-dose FDP (FDP-L), high-dose FDP (FDP-H), and a control group. Acute toxic hypoxia induced by carbon monoxide, sodium nitrite, and potassium cyanide and acute cerebral ischemic hypoxia were used to investigate the anti-hypoxia ability of FDP. The tests of rod-rotating, mouse tail suspension, and swimming endurance were used to explore the anti-fatigue effects of FDP. The Morris water maze experiment was used to determine the impact of FDP on learning and memory ability. Poisoning-induced hypoxic tests showed that mouse survival time was significantly prolonged in the FDP-L and FDP-H groups compared with the control group (p < 0.05). In the exhaustive swimming test, FDP significantly shortened struggling time and prolonged the time of mass-loaded swimming; the rod-rotating test showed that endurance time was significantly prolonged by using FDP (p < 0.05). FDP significantly decreased lactate and urea nitrogen levels and increased hepatic and muscle glycogen and glucose transporter-4 and Na+-K+-ATPase (p < 0.05). To conclude, FDP enhances hypoxia tolerance and fatigue resistance and improves learning and memory ability through regulating glucose and energy metabolism.
- Subjects
LEARNING ability; FRUCTOSE; POTASSIUM cyanide; SODIUM nitrites; ENERGY metabolism; MENTAL fatigue
- Publication
Canadian Journal of Physiology & Pharmacology, 2020, Vol 98, Issue 10, p733
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/cjpp-2019-0690