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- Title
Preparation and performance of <sup>99</sup>Mo/<sup>99m</sup>Tc chromatographic column generator based on zirconium molybdosilicate.
- Authors
Mostafa, M.; Saber, H. M.; El-Sadek, A. A.; Nassar, M. Y.
- Abstract
Zirconium molybdosilicate (ZrMoSi) gel prepared using 99Mo radiotracer via peroxo route was used as a base material for 99Mo/99mTc column generator. The 99mTc elution yield and 99Mo breakthrough in the eluate were studied as a function of the pH-value of gel precipitation, gel drying temperature and Zr:Mo:Si molar ratio. Precipitation pH-value of 2, drying temperature of 100 ℃ and Zr:Mo:Si molar ratio of 0.5:0.5:1 were found to be the optimum conditions achieving 99mTc elution yield of 82% and 99Mo breakthrough of 1.0E-3%. The gel prepared with the optimum conditions was characterized by BET surface area and pore size analyzer, IR spectroscopy, thermal analysis (TGA and DTA), XRD, XRF and FESEM. Technetium-99m eluted from the optimum ZrMoSi 99Mo/99mTc generator was found to have a high radiochemical purity (98% as 99mTcO4 -) and chemical purity meeting criteria of clinical grade.
- Subjects
ZIRCONIUM compounds; RADIOACTIVE tracers; MOLYBDENUM; COLUMN chromatography; PRECIPITATION (Chemistry); THERMAL analysis; PORE size (Materials)
- Publication
Radiochimica Acta, 2016, Vol 104, Issue 4, p257
- ISSN
0033-8230
- Publication type
Article
- DOI
10.1515/ract-2015-2488