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- Title
ABHD5—A Regulator of Lipid Metabolism Essential for Diverse Cellular Functions.
- Authors
Schratter, Margarita; Lass, Achim; Radner, Franz P. W.
- Abstract
The α/β-Hydrolase domain-containing protein 5 (ABHD5; also known as comparative gene identification-58, or CGI-58) is the causative gene of the Chanarin-Dorfman syndrome (CDS), a disorder mainly characterized by systemic triacylglycerol accumulation and a severe defect in skin barrier function. The clinical phenotype of CDS patients and the characterization of global and tissue-specific ABHD5-deficient mouse strains have demonstrated that ABHD5 is a crucial regulator of lipid and energy homeostasis in various tissues. Although ABHD5 lacks intrinsic hydrolase activity, it functions as a co-activating enzyme of the patatin-like phospholipase domain-containing (PNPLA) protein family that is involved in triacylglycerol and glycerophospholipid, as well as sphingolipid and retinyl ester metabolism. Moreover, ABHD5 interacts with perilipins (PLINs) and fatty acid-binding proteins (FABPs), which are important regulators of lipid homeostasis in adipose and non-adipose tissues. This review focuses on the multifaceted role of ABHD5 in modulating the function of key enzymes in lipid metabolism.
- Subjects
LIPID metabolism; CELL physiology; FATTY acid-binding proteins; PHOSPHOLIPASES; HOMEOSTASIS; ENZYME metabolism; ADIPOSE tissues
- Publication
Metabolites (2218-1989), 2022, Vol 12, Issue 11, p1015
- ISSN
2218-1989
- Publication type
Article
- DOI
10.3390/metabo12111015