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- Title
Editorial: Safety, Efficacy and Mechanisms of Action of Mesenchymal Stem Cell Therapies.
- Authors
Moll, Guido; Hoogduijn, Martin J.; Ankrum, James A.
- Abstract
Caplan et al. summarized how delivery methods shape the outcome of MSC therapy, differentiating between specific types of local and systemic delivery, and they further elaborate on the role of innate and adaptive immune responses, in particular cell product hemocompatibility aspects, on steering the clinical outcome. In line with this, Diedrichs et al. present their results on the clinical development of cardiac-derived MSC products and in particular the impact of interferon-gamma (IFN-g) inflammatory licensing on cell product properties in the context of allogeneic cell therapy. Clinical effects may result from a bi-directional crosstalk between MSCs and host cells (as long as MSCs are present), and from the initiation of secondary responses of varying duration, which complicates attempts to model kinetics and dosing in "cell pharmacology" ([11]). Oja et al. shared their hands-on experience on how freezing steps in MSC manufacturing impact quality and cell functionality attributes, and how a short-term 24-h culture recovery post thawing can restore the full functionality of the cells.
- Subjects
MESENCHYMAL stem cells; STEM cell treatment; BIOCHEMICAL mechanism of action; CELL physiology; BK virus; CYTOLOGY; RETINAL injuries
- Publication
Frontiers in Immunology, 2020, p1
- ISSN
1664-3224
- Publication type
Editorial
- DOI
10.3389/fimmu.2020.00243