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- Title
T lymphocyte subpopulations and la-positive T cells in patients with immunodeficiency.
- Authors
Williams JR, R. C.; Webster, A. D. B.; Morito, T.; Greaves, M. F.
- Abstract
T lymphocyte subpopulations (Tγ and Tμ) were studied in a group of 36 adult patients with immunodeficiency. Proportions and numbers of Ia(+) T cells were also studied in comparison to 46 normal adult controls. Values for per cent and total numbers of Tγ and Tμ cells indicated no uniform abnormality. Mean normal percentage of Ia(-F) T cells was 2.4% whereas 16 of 29 immunodeficient patients showed elevated proportions and absolute numbers of Ia(+) T cells. Striking fluctuation in proportions of Ia( + ) T cells was noted in serial studies of five immunodeficient subjects in contrast to similar analyses of normal controls, A correlation (P <0.01) was recorded between absolute numbers of Ia(-I-) T cells in immune deficiency patients and numbers of T/u, cells. Depletion of Tγ cells by EA rosetting in patients with late-onset primary acquired hypogammaglobulinaemia did not result in significant change in IgG or IgM synthesis when Tγ-depleted T cells were co-cultured with normal B cells. Depletion of Ia(+) T cells likewise did not significantly influence Ig synthesis in co-culture with normal or immune-deficient B cells. These studies emphasize the complexity of defects present among any large group of patients with immune deficiency.
- Subjects
T cells; LYMPHOCYTES; IMMUNODEFICIENCY; IMMUNOSUPPRESSION; B cells; IMMUNITY
- Publication
Clinical & Experimental Immunology, 1980, Vol 42, Issue 2, p355
- ISSN
0009-9104
- Publication type
Article