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- Title
C-Terminal to Intact Fibroblast Growth Factor 23 Ratio in Relation to Estimated Glomerular Filtration Rate in Elderly Population.
- Authors
Bożentowicz-Wikarek, Maria; Owczarek, aleksander; Kocełak, Piotr; Olszanecka-Glinianowicz, Magdalena; Więcek, andrzej; Chudek, Jerzy
- Abstract
Background/Aims: An analytical equivalence between intact fibroblasts growth factor (iFGF23) and C-terminal (cFGF23) assays is logically expected, however, numerous studies demonstrate lack of a strong association between them. Previously, we have demonstrated the increase in cFGF23 slightly precedes the increase of iFGF23 with the impairment of kidney excretory function; without actually analyzing the ratio between both assays, which are postulated to be affected by declining kidney function. Therefore, the aim of this study was to analyze the ratio between C and iFGF23 in relation to the estimated glomerular filtration rate (eGFR) in an elderly population. Methods: We analysed the variability of c/iFGF23 ratio in the population of 3264 elderly PolSenior study participants (≥ 65years) in the relation to eGFR calculated according full Modification of Diet in Renal Disease, serum levels of C-reactive protein (hs- CRP), and iron. Results: The log10 (c/i FGF23 ratio) increased in the subsequent CKD stages. Serum iron and CRP levels reduced the log10 and increased it with age in multivariate regression analysis. Conclusions: Our results suggest impairment in the cleavage of the C-terminal FGF23 fragments with the deterioration of kidney excretory function and age in the elderly population. Inflammation and low serum iron level seems to diminish degradation capacity of FGF23 fragments.
- Subjects
CHRONIC kidney failure; FIBROBLAST growth factors; GLOMERULAR filtration rate; DISEASES in older people; CHRONIC diseases
- Publication
Kidney & Blood Pressure Research, 2016, Vol 41, Issue 5, p519
- ISSN
1420-4096
- Publication type
Article
- DOI
10.1159/000443452