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- Title
Piptadenia gonoacantha-based natural dermocosmetic: a clinical trial.
- Authors
Paiva, Luciano Côrtes; da Silva, Karen Vieira; Guarçoni de Almeida, Gabriel Feu; de Carvalho Caldeira, Eliana Amaro; Soares Gazzinelli Cruz, Carlos Eduardo; Oliveira Salgado, Patrícia de; Oliveira Fani Amaro, Marilane de; de Carvalho, Camilo Amaro
- Abstract
The use of phytotherapy expands the possibility of therapeutic resources for the population, often offering reduced costs when compared to the pharmaceutical industry. In this perspective, the JACBIO® dermocosmetic ointment revealed, in non-clinical trials, its antibacterial and healing potential, with a great stimulating effect in increasing the production of images. This work aimed to carry out the clinical phase study on dermal toxicity, in serious humans, by applying JACBIO®, based on extracts from the leaves of Piptadenia gonoacantha (Pau Jacaré). The phase I randomized clinical trial was carried out with 28 clinically healthy patients at a public university in Minas Gerais, with no period from August to December 2018. The toxicological trial was developed with the intervention group that received a JACBIO® dermatological ointment and the Placebo group. From the experimental protocol, participants were followed for four weeks. An analysis between the ointment and placebo groups, without reference to anticholinergic and cardiovascular events, showed no statistically significant difference. Likewise, there was no difference in laboratory results performed before and after treatment, both for the placebo group and for the intervention group. A low toxicity of the product indicates that this adjustment is safe and serves as a basis for phase II clinical trials in patients with lesions.
- Subjects
MINAS Gerais (Brazil); CLINICAL trials; DRUGS; HEALING; PUBLIC universities &; colleges; CARDIOVASCULAR diseases
- Publication
Revista Ciência e Natura, 2021, Vol 43, p1
- ISSN
0100-8307
- Publication type
Article
- DOI
10.5902/2179460X43676