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- Title
Activation of the rat olfactory bulb by direct ventral stimulation after nerve transection.
- Authors
Coelho, Daniel H.; Socolovsky, Leandro D.; Costanzo, Richard M.
- Abstract
Background: The aim of this study was to demonstrate how direct electrical stimulation can activate the olfactory bulb after denervation of the olfactory nerve input. Methods: Sprague‐Dawley rats (n = 5) were anesthetized and olfactory bulbs exposed. Olfactory nerves were transected by passing a Teflon blade between the cribriform plate and ventral surface of the bulb. A cochlear implant electrode array was used to stimulate 6 different positions along the ventral surface of the olfactory bulb. Biphasic constant‐current pulses were used (50‐1000 μA, 50–1000 μs) to stimulate the bulb, and a 16‐electrode paddle array was used to record localized negative field potential responses at the dorsal surface of the bulb. Results: Localized negative field potentials were reliably obtained using biphasic, 500‐μA, 200‐μs pulses. A shift in stimulating position by 1 mm resulted in a significant change in the dorsal field potential. Conclusion: Direct stimulation of the deafferented olfactory bulb was effective in generating localized field potential responses. These findings support the potential use of direct electrical stimulation for the treatment of anosmia.
- Subjects
SPRAGUE Dawley rats; OLFACTORY bulb; LIMBIC system; ANOSMIA; BIPHASIC insulin; PHYSIOLOGY
- Publication
International Forum of Allergy & Rhinology, 2018, Vol 8, Issue 8, p922
- ISSN
2042-6976
- Publication type
Article
- DOI
10.1002/alr.22133