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- Title
Effect of Punica granatum peel extract on learning and memory in rats
- Authors
Adiga, Shalini; Trivedi, Prabhav; Ravichandra, V; Deb, Debashree; Mehta, Forum
- Abstract
Abstract: Objective: To evaluate potential memory enhancing effect of Punica granatum peel extract on rats. Methods: Healthy adult male albino rats of Wistar strain were used. Each group of 6 rats were administered either distilled water or 50 mg/kg of extract or 100 mg/kg of extract for 15 days and subjected to passive avoidance test or T-maze test. In the next phase rats were administered distilled water or 100 mg/kg of extract for 15 days and the rats were given injection diazepam before subjecting them to the tests. Results: The overall performance was better in test groups compared to control groups. Among the test groups, 100 mg/kg rats performed better than 50 mg/kg. The effect on spatial learning parameters like mean number of alternations and mean percentage bias was more marked compared to retention testing parameters like latency. 100 mg/kg Punica extract treated group also improved performance of diazepam treated rats. Conclusions: There is a definite trend of memory improvement by Punica granatum peel with effects being more marked on spatial learning tendency and long term memory than on retention capacity.
- Subjects
PUNICA; DIAZEPAM; RATS; LONG-term memory; DISTILLED water
- Publication
Asian Pacific Journal of Tropical Medicine, 2010, Vol 3, Issue 9, p687
- ISSN
1995-7645
- Publication type
Article
- DOI
10.1016/S1995-7645(10)60166-6