We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Caffeic acid, CAPE, skin, regeneration, wound healing, CAPE synthetic derivatives, quinolone, isoquinoline.
- Authors
Franco, Caterina; Sciatti, Edoardo; Favero, Gaia; Vizzardi, Enrico; Rezzani, Rita
- Abstract
Oxidative stress and chronic inflammation are well known as potential responsible for many cardiovascular diseases (Lim et al., 2012; Mancia et al., 2013). The clinical trial, approved by the Ethics Committee of the ASST Spedali Civili (code NP 2717, authorized Prot. n. 0042068, approved 04.07.2017), was born for understanding if intervening on the inflammatory and oxidative cascade that seems to result in the development of hypertension, it is possible to restore an oxidative balance leading to positive results even at the endothelial and vascular level. Among all the antioxidant molecules, melatonin was chosen for its well-known role as a powerful antioxidant and anti-inflammatory molecule. The study involved 23 patients, aged between 45 and 60 years old, with BMI <30 kg/m2, diagnosed with essential hypertension but no other cardiovascular or autoimmune diseases and conditions or habits that could alter the oxidative background. They were randomly assigned to 2 groups: "melatonin" in which patients have been asked to add to their antihypertensive therapy the intake of 1 mg/day of melatonin for a year and a "control" group in which there were no changes in the therapeutic scheme. Both groups underwent an evaluation before the start (T0) and at the end of the study (1 year later - T1) in which were considered: 1. total antioxidant capacity and melatonin concentration in plasma obtained from venous withdrawal; 2. endothelial dysfunction and 3. arterial stiffness. It was possible to define that at T0 53% of patients belonging to the melatonin group presented with endothelial damage, whereas 40% presented with an altered arterial stiffness. At T1, in the patients supplemented with melatonin, we find out that the arterial stiffness index decreased in a statistically significant way, next to a significant decrease in total antioxidant capacity plasma values. We hypothesized that a correlation between total antioxidant capacity and arterial stiffness exists and that the combination between antihypertensive therapy and antioxidant supplementation could improve the vascular health and functionality (Vlachopoulos et al., 2015; Tembo et al., 2020).
- Subjects
CAFFEIC acid; OXIDANT status; ISOQUINOLINE; HEALING; ARTERIAL diseases; ENDOTHELIUM diseases; ORAL habits
- Publication
Italian Journal of Anatomy & Embryology / Archivio Italiano di Anatomia Ed Embriologia, 2021, Vol 125, p105
- ISSN
1122-6714
- Publication type
Article