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- Title
Benefits of Curcumin Supplementation on Antioxidant Status in β-Thalassemia Major Patients: A Double-Blind Randomized Controlled Clinical Trial.
- Authors
Esmat Nasseri; Elahe Mohammadi; Ahmad Tamaddoni; Durdi Qujeq; Farid Zayeri; Hamid Zand
- Abstract
Background: β-Thalassemia major, the most common inherited anemia in the world, is associated with imbalance in the oxidant-antioxidant system. The objective of this study was to evaluate the efficacy of curcumin supplementation on markers of oxidative stress in patients with β-Thalassemia. Methods: This double-blind randomized controlled clinical trial was performed on 61 β-thalassemia major patients. Subjects in the curcumin group received two 500 mg curcumin capsules daily and patients in the placebo group took 2 placebo capsules daily for 12 weeks. Dietary intakes and biochemical parameters were assessed at the beginning and the end of intervention. Results: At the end of the study, serum malondialdehyde (MDA), total and direct bilirubin significantly decreased ( p = 0.002, p < 0.001, and p < 0.001, re- spectively) and total antioxidant capacity significantly increased ( p = 0.005) in the curcumin group. Based on the analysis of covariance, a significant reduction in MDA, total and direct bilirubin was also detected in the curcumin group when compared to the placebo group ( p = 0.001, p = 0.039, and p = 0.013, respectively). Changes in hemoglobin, serum iron, ferritin, catalase, and vitamin E were not significant in any of the 2 groups. Conclusions: Curcumin supplementation in combination with deferoxamin improved the antioxidant status in β-thalassemia major patients. Curcumin may be useful for the relief of metabolic complications in these patients.
- Subjects
DEFEROXAMINE; ANALYSIS of covariance; ANTIOXIDANTS; BILIRUBIN; DIETARY supplements; LONGITUDINAL method; NUTRITIONAL assessment; PROBABILITY theory; STATISTICAL sampling; MALONDIALDEHYDE; STATISTICAL significance; OXIDATIVE stress; RANDOMIZED controlled trials; BLIND experiment; BETA-Thalassemia; CURCUMIN; THERAPEUTICS
- Publication
Annals of Nutrition & Metabolism, 2018, Vol 71, Issue 3/4, p136
- ISSN
0250-6807
- Publication type
Article
- DOI
10.1159/000479634