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- Title
A Sustainable One-Pot, Two-Enzyme Synthesis of Naturally Occurring Arylalkyl Glucosides.
- Authors
Bassanini, Ivan; Krejzová, Jana; Panzeri, Walter; Monti, Daniela; Křen, Vladimir; Riva, Sergio
- Abstract
A sustainable, convenient, scalable, one-pot, two-enzyme method for the glucosylation of arylalkyl alcohols was developed. The reaction scheme is based on a transrutinosylation catalyzed by a rutinosidase from A. niger using the cheap commercially available natural flavonoid rutin as glycosyl donor, followed by selective 'trimming' of the rutinoside unit catalyzed by a rhamnosidase from A. terreus. The process was validated with the syntheses of several natural bioactive glucosides, which could be isolated in up to 75 % yield without silica-gel chromatography.
- Subjects
GLUCOSIDES; FLAVONOIDS; RUTIN; GLYCOSIDES; SACCHARIDES; NORMAL-phase chromatography
- Publication
ChemSusChem, 2017, Vol 10, Issue 9, p2040
- ISSN
1864-5631
- Publication type
Article
- DOI
10.1002/cssc.201700136