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- Title
One-step multicomponent synthesis of chiral oxazolinyl-zinc complexes.
- Authors
Mei Luo; Jing Cheng Zhang; Wen Min Pang; King Kuok Hii
- Abstract
Background: Typically, oxazolinyl metal complexes are synthesized in two steps, where the free ligand is prepared by the condensation reaction between a functionalized nitrile and an amino alcohol in the presence of a Lewis or Brønsted acid catalyst, followed by a further reaction with metal salts to obtain the corresponding metal complexes. Very often, the yield afforded by the two-step procedure is not high, and very few oxazolinyl zinc complexes have been prepared by this route. Given that metal-oxazoline complexes often contain Lewis acidic metals, it is conceivable that the two steps may be telescoped. Results: A series of novel chiral organozinc complexes 1-15 were assembled in a single step, All crystalline compounds were fully characterized, including the report of 15 X-ray crystal structures, including a wide structural diversity. Conclusions: A series of novel chiral organozinc complexes were assembled in a single step, from nitriles, chiral D/L amino alcohols, and a stoichiometric amount of ZnCl2, with moderate to high yields (20-90%).
- Subjects
METAL complexes; CONDENSATION reactions; AMINO alcohols; LEWIS acids; X-ray crystallography
- Publication
Chemistry Central Journal, 2017, Vol 11, p1
- ISSN
1752-153X
- Publication type
Article
- DOI
10.1186/s13065-017-0305-1