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- Title
Histomorphometry of tissue repair after the use of formulations based on extracts of Piptadenia gonoacantha (Mart.) J. F. Macbr in mice.
- Authors
Pereira Ribeiro, Cássia Gondim; de Oliveira Fani Amaro, Marilane; Frescura, Lucas Mironuk; de Ávila, Mariane Borges Rodrigues; da Rosa, Marcelo Barcellos; de Carvalho, Camilo Amaro; Xavier, Juliana Cantele
- Abstract
Piptadenia gonoacantha is a tree species with several biological properties. The objective of this study was to evaluate the action of two pharmaceutical formulations, ointment, and balm, containing Piptadenia gonoacantha extract, on the healing of wounds made in 45-day-old male mice. The animals were randomly grouped and 3 treatments with 6 repetitions: an ointment containing the extract; balm containing the extract and silver sulfadiazine was used as the positive control. Tissue samples were collected on the 4th and 8th days. Treatment began immediately after the injury, and the treatments were applied once a day throughout the experiment. Treatment with the balm formulations on day 4 and the ointment on day 8 had better wound area regression rates compared to the control group, 45.4% and 81.6%, respectively. The balm and ointment treatments provided a reduction in vascularity indicating a reduction in the inflammatory process, initiating the proliferative phase in the scar tissue. These data were supported by the analysis of collagen synthesis. The results pointed out the efficacy of balm and ointment formulations concerning sulfadiazine. Therefore, the balm formulation is indicated for the beginning of the treatment, while the ointment formulation is indicated for the continuation and end of treatment.
- Subjects
END of treatment; HISTOMORPHOMETRY; SCARS; WOUND healing; SILVER sulfadiazine
- Publication
Archives of Veterinary Science, 2024, Vol 29, Issue 1, p1
- ISSN
1517-784X
- Publication type
Article
- DOI
10.5380/avs.v29i1.93460