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- Title
Impact of Nucleos(t)ide Reverse Transcriptase Inhibitors on Blood Telomere Length Changes in a Prospective Cohort of Aviremic HIV-Infected Adults.
- Authors
Montejano, Rocio; Stella-Ascariz, Natalia; Monge, Susana; Bernardino, José I; Pérez-Valero, Ignacio; Montes, Maria Luisa; Valencia, Eulalia; Martín-Carbonero, Luz; Moreno, Victoria; González-Garcia, Juan; Bernardino, José I; Pérez-Valero, Ignacio; Martín-Carbonero, Luz; González-Garcia, Juan; Rodriguez-Centeno, Javier; Rodes, Berta; Cantos, Andres Esteban; Alejos, Belen; de Miguel, Rosa; Arnalich, Francisco
- Abstract
<bold>Background: </bold>Tenofovir is a potent inhibitor of human telomerase. The clinical relevance of this inhibition is unknown.<bold>Methods: </bold>A prospective cohort of human immunodeficiency virus (HIV)-infected participants with suppressed virological replication was recruited to compare whole-blood telomere length (measured by quantitative multiplex polymerase chain reaction analysis) in participants with current exposure to tenofovir disoproxil fumarate (TDF) to that in participants never exposed to TDF.<bold>Results: </bold>A total of 172 participants were included: 67 were in the TDF group, and 105 were in the non-TDF group (75 were receiving 2 nucleosides [of whom 69 were receiving abacavir], 25 were receiving a nucleos[t]ide reverse transcriptase inhibitor [N{t}RTI]-sparing regimen, and 5 were receiving lamivudine as the only nucleoside). After 2 years, the mean blood telomere length increased significantly in the whole cohort. The TDF group had significantly smaller gains in telomere length than the non-TDF group. In the analysis restricted to participants receiving N(t)RTIs, TDF exposure was not associated with an independent negative effect. In the non-TDF group, participants treated with 2 nucleosides also had significantly smaller gains in telomere length than those receiving N(t)RTI-sparing regimens or lamivudine as the only nucleoside.<bold>Discussion: </bold>In HIV-infected adults with prolonged virological suppression, treatment with TDF or abacavir was associated with smaller gains in blood telomere length after 2 years of follow-up.
- Publication
Journal of Infectious Diseases, 2018, Vol 217, Issue 12, pN.PAG
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiy364